10 Biggest Orthopedic Manufacturers in the World

State-of-the-art orthopedic manufacturing equipment in use at a modern facility.
Find a list of the 10 biggest orthopedic manufacturers globally, their products, and contact information.

New forms of technology continuously shape the orthopedic device industry. With their experience, expertise, and deep pockets, large orthopedic manufacturers regularly invest in R&D and acquire innovative companies. They have the scale to make products accessible in many markets and (hopefully) keep prices reasonable. Many large manufacturers run training programs for surgeons, too.

When orthopedic surgeons keep up with manufacturers’ products and services, patients benefit. You can compare each company’s products and services to propose devices that meet your patients’ needs and budgets. Large manufacturers’ R&D interests and investments indicate which new devices and procedures will soon become a reality, and an option for your patients.

Below are 10 of the biggest orthopedic manufacturers in the world. (We’ve listed them alphabetically.)

1. Arthrex

Arthrex develops arthroplasty and orthobiologics products, as well as devices for shoulder, knee, elbow, hand, foot, and hip orthopedic procedures. The company helped pioneer the field of arthroplasty and claims to develop more than 1,000 products and procedures every year. It also provides medical education programs for orthopedic surgeons at six ArthroLab locations in Europe, Asia, and North and South America.

Arthrex’s products are now used in over 150 countries. In 2021, the manufacturer earned $2.6 billion in total revenue.

Headquarters: 1370 Creekside Blvd, Naples, Florida 34108, USA

Phone: (800) 933-7001 (US toll-free)

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2. DePuy Synthes

DePuy Synthes is the orthopedic device company of the Johnson & Johnson Medical Devices group. Its portfolio includes craniomaxillofacial, spinal surgery, joint reconstruction, trauma, and sports medicine. It also offers a personalized planning service for knee implants based on a patient’s anatomy. Through the J&J Institute, DePuy Synthes offers virtual courses, webinars, telementoring, virtual-reality training, and hands-on education.

The company was founded as DePuy Manufacturing in 1895 to produce customizable fiber splints as an alternative to wooden splints. A series of mergers and acquisitions allowed DePuy Manufacturing to expand its portfolio. Johnson & Johnson bought DePuy in 1998 and later combined it with Synthes, another acquisition. In 2021, Johnson & Johnson’s medical devices business earned $27.06 billion

Headquarters: 325 Paramount Drive, Raynham, Massachusetts 02767, USA

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3. Enovis

Enovis is a global orthopedic device manufacturer with more than 1,000 products for pain management, physical therapy, and rehabilitation. The company offers cutting-edge technology like shockwave therapy devices and an augmented reality (AR) guidance system for knee and hip replacement surgery. Enovis also offers a range of DME software used by 38,000 providers, as well as a patient-care app and e-commerce sites for orthopedic products.

Enovis Corporation was formed in 2022 after Colfax Corporation spun off its industrial manufacturing business to focus on medical technology. In 2019, Colfax had acquired DJO Global, an orthopedic device manufacturer. Enovis has since acquired two more entities: Insight Medical Systems, a maker of AR surgical guidance tech, and 360 Med, a developer of joint replacement technology. The company earned $2.82 billion in revenue in 2022

Headquarters: 2711 Centerville Road, Suite 400, Wilmington, DE 19808, USA

Phone: +1 302 252 9160

Email: info@enovis.com

4. Globus Medical

Globus Medical develops and manufactures musculoskeletal device solutions, focusing on biologics, spine, trauma, and joint reconstruction technology. It also offers Excelsius™, an integrated surgical system with robotic navigation and intelligent imaging. Globus runs education and research programs for orthopedic professionals.

The company was founded in the USA in 2003 and entered the international market in 2018. It acquired at least six companies over the years, the latest being Synoste, a Finnish startup that created an implant for correcting leg-length discrepancy. Globus Medical earned $998 million in the 12 months ending September 30, 2022.

Headquarters: 2560 General Armistead Avenue, Audubon, PA 19403, USA

Phone: +1 610 930 1800

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5. Medtronic

Medtronic’s portfolio encompasses four segments: cardiac and vascular, diabetes, minimally invasive therapies, and restorative therapies. The company’s orthopedic products include devices for minimally invasive spinal and sports surgery, such as tools for simplified bone grafting, modular screws, and a robotics and navigation system. It's particularly strong in interbody science innovation, with developments like surface technology for titanium interbodies.

Earl Bakken, an engineer, co-founded Medtronic in 1949 and later created the first wearable, battery-powered pacemaker. Today, the company’s products are used in more than 150 countries. Medtronic earned $31.686 billion in the 12 months ending October 31, 2022.

Headquarters: 710 Medtronic Parkway, Minneapolis, MN 55432-5640, USA

Phone: +1 763 514 4000

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6. NuVasive

NuVasive creates medical devices and procedures for minimally invasive spine surgery. It develops surface and structural technologies for PEEK and titanium implants. It also offers a specialized orthopedics platform comprising magnetically adjustable implant systems. NuVasive provides surgeon education in hands-on cadaver labs in Amsterdam and San Diego.

The company was formed in 1997 and now operates in more than 50 countries. Over the years, it acquired five other companies, with the most recent being Simplify, a developer of artificial cervical discs for the spine. NuVasive earned $1.139 billion in 2021.

Headquarters: 7475 Lusk Boulevard, San Diego, CA 92121, USA

Phone: +1 858 909 1800

Email: info@nuvasive.com 

7. Orthofix Medical (Orthofix-SeaSpine)

Orthofix Medical specializes in biologics, bone growth therapies, and minimally invasive orthopedic medical devices. Its allograft solutions have been applied in more than 350,000 procedures globally. The company also provides surgeon training courses, hospital observerships, and peer-to-peer education.

Orthofix Medical is the combined entity of two manufacturers, Orthofix and SeaSpine, which announced a “merger of equals” in October 2022. Both companies have become multinational players and the combined entity now has products distributed in nearly 70 countries. In 2022, Orthofix made $460.7 million in revenue while SeaSpine earned $237.9 million.

Headquarters: 3451 Plano Parkway, Lewisville, TX 75056, USA

Phone: +1 214 937 2000

8. Smith+Nephew

Smith+Nephew offers medical devices for orthopedic reconstruction, minimally invasive joint repair, and trauma fixation. Its core offerings include high-tech wound-care products and a robotics-assisted orthopedic surgery system. Smith+Nephew is known for building one of the most clinically successful partial knees. In 2021, the manufacturer introduced a cementless total knee system made with proprietary 3D-printed porous titanium.

The company was founded in 1856 and acquired several businesses specializing in orthopedics, surgical devices, and wound care throughout the 1900s and 2000s. Today, Smith+Nephew products are sold in more than 100 countries. Revenue for 2021 amounted to $5.2 billion.

Headquarters: Building 5, Croxley Park, Hatters Lane, Watford, Hertfordshire WD18 8YE, UK

Phone: +44 1923 477 100

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9. Stryker

Stryker offers a comprehensive orthopedics portfolio, which includes joint replacement, sports medicine, trauma, spine, foot and ankle, and other areas. Its digital healthcare platform uses 4K imaging to guide surgeons and robotic devices. It also offers IoT systems like sensor-assisted total knee arthroplasty and the world’s first completely wireless hospital bed.

Stryker’s roots date back to 1941. Today, its products are sold in more than 100 countries. The company earned a revenue of $17.948 billion in the ​​twelve months leading up to September 30, 2022.

Headquarters: 2825 Airview Boulevard, Kalamazoo, Michigan 49002, USA

Phone: +1 269 385 2600

10. Zimmer Biomet

Zimmer Biomet creates products and solutions for limb salvage, biologics, trauma, sports medicine, and a wide range of anatomical regions. Its advanced digital solutions include a robotics and navigation platform for knee, hip, and brain procedures. The company also offers an intelligence suite driven by AI and IoT to monitor patient recovery and predict risk factors for individual patients. Zimmer Biomet’s FDA-approved smart knee implant is the first ortho device of its kind in the world.

Founded in 1927 as a maker of aluminum splints, Zimmer later acquired several companies, including Biomet, an orthopedic device manufacturer, in 2015. The company sells its products in more than 100 countries and earned $7.901 billion in revenue in the twelve months ending September 30, 2022.

Headquarters: 1800 W Center St Warsaw, Indiana 46580, USA

Phone: +1 800 613 6131

Email: contactus@zimmerbiomet.com 

Keep track of orthopedic device concepts, tests, and launches

News from the orthopedic industry’s biggest manufacturers are just one way to keep up with new devices and procedures. Check out our list of top orthopedic journals to stay updated on innovations and research in the industry.

Photo by Sean Pollock

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